Ergo, those countries are much more fat than the US

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The data are analysed using a binding model that includes lipid aggregation and the explicit association of water with the lipid. For a series of substituents (OMe, Me, H, F, Cl steroids, Br, I, NO2) at the 5 position of the indole ring, the trends in the free energy of association for the formation of 1 : 1 and 1 : 2 lipid tryptophan adducts both follow an inverted U relationship as a function of the corresponding para Hammett parameter, with tryptophan (R = H) exhibiting the weakest binding. These trends are shown to be consistent with participation of the indole side chain in both hydrogen bonds and cation pi interactions.

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